Treatment of enterococcal endocarditis; 2 4 6 7 used in conjunction with an aminoglycoside. REFERENCES 1. Clinical and Laboratory Standards Institute CLSI. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-fifth Informational Supplement. CLSI document M100-S25. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. 2. Clinical and Laboratory Standards Institute CLSI. Performance Standards for Antimicrobial Disk Susceptibility Test; Approved Standard-Twelfth Edition. CLSI document M02-A12. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. 3. Clinical and Laboratory Standards Institute CLSI. Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically; Approved Standard-Tenth Edition. CLSI document M07-A10. Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015. ebade.info evista
HACEK microorganisms include Haemophilus parainfluenzae, H aphrophilus, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae. Treatment with ampicillin does not preclude the need for surgical procedures, particularly in staphylococcal infections. After the diagnosis of pseudomembranous colitis has bean established, measures should be initiated. Mild cases of pseudomembranous colitis usually respond to drug discontinuation alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, supplementation and treatment with an antibacterial drug clinically effective against colitis.
If your symptoms do not improve within a few days, or if they become worse, check with your doctor. AUC in rats. Results of these studies did not reveal evidence of teratogenicity to the fetus. However, animal reproduction studies are not always predictive of human response. Ketorolac plasma levels. Therapeutic concentrations of digoxin, warfarin, ibuprofen, naproxen, piroxicam, acetaminophen, phenytoin and tolbutamide did not alter Ketorolac tromethamine protein binding. AAP states oral route is inappropriate for severe infections. Periodically assess organ system functions, including renal, hepatic, and hematopoietic, during prolonged therapy.
Use eye drops before eye ointments to allow the drops to enter the eye. Ketorolac tromethamine is contraindicated as prophylactic analgesic before any major surgery. Craig WA, Gerber AU "Worldwide experience with bacampicillin administered twice a day. Prevention and prompt treatment are important because group B strep infections may become life-threatening among newborns. Set up a well-baby check-up before you leave the hospital. Jaundice is usually at its worst around day 5, so have the visit within the first 5 days after your child's birth. The doctor will check your baby for jaundice that is of any concern.
Renal impairment: Use with caution in patients with renal impairment; dosage adjustment recommended. Generalized seizures have been described in 2 patients during treatment with ampicillin, although in both cases, there were underlying disease factors that may have predisposed the patients to seizure activity. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine Ty21a should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Has been used to treat and prevent secondary pulmonary infections in patients with pertussis. 9 Erythromycin generally considered drug of choice for treatment of catarrhal stage of pertussis and to shorten the period of communicability of the disease. 5 9 Ampicillin, like most other anti-infectives, does not shorten clinical course of pertussis.
Enoxaparin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using enoxaparin at home, a health care provider will teach you how to use it. Be sure you understand how to use enoxaparin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. Patients should be managed by symptomatic and supportive care following a NSAIDs overdose. There are no specific antidotes. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. In cases of overdose, discontinue medication, treat symptomatically, and institute supportive measures as required. In patients with renal function impairment, Ampicillin-class antibiotics can be removed by hemodialysis but not peritoneal dialysis. ventolin
If you miss a dose, skip the missed dose and resume your usual dosing schedule. The liquid form of this medicine is best taken with a full glass 8 ounces of water on an empty stomach either 1 hour before or 2 hours after meals unless otherwise directed by your doctor. Physicians are cautioned to use no less than the above recommended dosage for the treatment of gonorrhea. Follow-up cultures should be obtained from the original sites of infection 7 to 14 days after therapy. In women, it is also desirable to obtain culture test-of-cure from both the endocervical and anal canals. Prolonged intensive therapy is needed for complications such as prostatitis and epididymitis. Cases of gonococcal with a suspected of syphilis should have darkfield examinations ruling out syphilis before receiving ampicillin. Patients who do not have suspected lesions of syphilis and are treated with ampicillin should have a follow- up serologic test for syphilis each month for four months to detect syphilis that may have been masked from treatment for gonorrhea. Ask your doctor before you change your diet or the dose of your diabetes medicine. When intrapartum GBS prophylaxis is indicated, IV penicillin G is the drug of choice. Although IV ampicillin can be used, CDC and AAP state that penicillin G is preferred since it has a narrower spectrum of activity and is less likely to select for antibiotic-resistant organisms. IV administration of UNASYN. The concurrent administration of allopurinol and Ampicillin increases substantially the incidence of skin rashes in patients receiving both drugs as compared to patients receiving Ampicillin alone. It is not known whether this potentiation of Ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Read the Patient Information Leaflet and instruction sheet if available from your before you start using aclidinium and each time you get a refill. Learn how to use this properly. If you have any questions, ask your doctor or pharmacist. Kucers A, Crowe S, Grayson ML et al, eds. The use of antibiotics. A clinical review of antibacterial, antifungal, and antiviral drugs. What happens if I overdose Principen? Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure black-out or convulsions. Hypersensitivity Reactions: An erythematous, mildly pruritic, maculopapular skin rash has been reported fairly frequently. The rash, which usually does not develop within the first week of therapy, may cover the entire body including the soles, palms, and oral mucosa. The eruption usually disappears in three to seven days. Other hypersensitivity reactions that have been reported are: skin rash, pruritus, urticaria, erythema multiforme, and an occasional case of exfoliative dermatitis. Anaphylaxis is the most serious reaction experienced and has usually been associated with the parenteral dosage form of the drug. Ampicillin, uses the 10 mcg Ampicillin disk. Interpretation involves correlation of the diameter obtained in the disk test with the minimum inhibitory concentration MIC for Ampicillin. Whenever such reactions occur, ampicillin should be discontinued unless, in the opinion of the physician, the being treated is life-threatening, and amenable only to ampicillin therapy. Septicemia and Endocarditis caused by susceptible Gram-positive organisms including Streptococcus spp. For IV use: The manufacturer product information should be consulted. UNASYN possesses the properties of a broad-spectrum antibacterial and a beta-lactamase inhibitor. This is not a complete list of possible side effects. CAUTION: NOT TO BE DISPENSED AS A UNIT. Importance of taking oral ampicillin with a full glass of water 1 hour before or 2 hours after a meal. buy mirtazapine rome
Ketorolac tromethamine should be used with caution in patients with impaired hepatic function or a history of liver disease. Borderline elevations of one or more liver tests may occur in up to 15% of patients taking NSAIDs including Ketorolac tromethamine. These laboratory abnormalities may progress, may remain unchanged, or may be transient with continuing therapy. Notable elevations of ALT or AST approximately three or more times the upper limit of normal have been reported in approximately 1% of patients in clinical trials with NSAIDs. In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis and hepatic failure, some of them with fatal outcomes have been reported. What is the most important information I should know about ampicillin Principen? The dosages in have generally proved satisfactory and are recommended as a guide for use in the average adult. These dosages should be reduced for elderly or debilitated patients. Until further experience is gained, Marcaine is not recommended for pediatric patients younger than 12 years. Marcaine is contraindicated for obstetrical paracervical blocks, and is not recommended for intravenous regional anesthesia Bier Block. Penicillin G usually preferred for N. meningitidis meningitis and penicillin-susceptible S. pneumoniae meningitis. 5 For H. influenzae meningitis, cefotaxime, ceftriaxone, or, alternatively, ampicillin in conjunction with chloramphenicol is recommended; ampicillin should not be used alone see Ampicillin-resistant Haemophilus influenzae under Cautions. Committee on Infectious Diseases, American Academy of Pediatrics. Red book: 2000 report of the Committee on Infectious Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000. Penicillin or ampicillin resistance among enterococci due to beta-lactamase production has been reported very rarely. Penicillin or ampicillin resistance due to beta-lactamase production is not reliably detected with routine disk or dilution methods, but is detected using a direct, nitrocefin-based beta-lactamase test. Because of the rarity of beta-lactamase-positive enterococci, this test need not be performed routinely, but can be used in selected cases. Eleventh Edition. CLSI document M02-A11. As with other NSAIDs, anaphylactoid reactions may occur in patients without a known previous exposure or hypersensitivity to Ketorolac tromethamine. Ketorolac tromethamine should not be given to patients with the aspirin triad. This symptom complex typically occurs in asthmatic patients who experience rhinitis with or without nasal polyps, or who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs see and PRECAUTIONS, . Anaphylactoid reactions, like anaphylaxis, may have a fatal outcome. Emergency help should be sought in cases where an anaphylactoid reaction occurs. UNASYN may result in increased and prolonged blood levels of ampicillin and sulbactam. Benedict's Solution or Fehling's Solution. Many other diseases and illnesses may cause bad breath. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated. This medication may contain aspartame. If you have phenylketonuria PKU or any other condition that requires you to restrict your intake of aspartame or consult your doctor or pharmacist regarding the safe use of this medicine. Infectious mononucleosis: A high percentage of patients with infectious mononucleosis have developed rash during therapy; ampicillin-class antibiotics not recommended in these patients. Rash generalized maculopapular and pruritic usually appears 7 to 10 days after initiation and usually resolves within a week of discontinuation. Clinical trials of several COX-2 selective and nonselective NSAIDs of up to three years duration have shown an increased risk of serious cardiovascular CV thrombotic events, including myocardial infarction MI and stroke, which can be fatal. Based on available data, it is unclear that the risk for CV thrombotic events is similar for all NSAIDs. The relative increase in serious CV thrombotic events over baseline conferred by NSAID use appears to be similar in those with and without known CV disease or risk factors for CV disease. However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate. Some observational studies found that this increased risk of serious CV thrombotic events began as early as the first weeks of treatment. The increase in CV thrombotic risk has been observed most consistently at higher doses. Depending upon the route of administration, local anesthetics are distributed to some extent to all body tissues, with high concentrations found in highly perfused organs such as the liver, lungs, heart, and brain.
For genitourinary or tract infections other than gonorrhea in men and women, the usual dose is 500 mg in equally spaced doses; severe or infections may require larger doses. Neurologic effects following epidural or caudal anesthesia may include spinal block of varying magnitude including high or total spinal block; hypotension secondary to spinal block; urinary retention; fecal and urinary incontinence; loss of perineal sensation and sexual function; persistent anesthesia, paresthesia, weakness, paralysis of the lower extremities and loss of sphincter control all of which may have slow, incomplete, or no recovery; headache; backache; septic meningitis; meningismus; slowing of labor; increased incidence of forceps delivery; and cranial nerve palsies due to traction on nerves from loss of cerebrospinal fluid. The mean serum half-life of both drugs is approximately 1 hour in healthy volunteers. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Learn when you can treat sudden by yourself and when you must get medical help right away. This medication contains sodium. generic minomycin order online payment
For solution and drug compatibility information, see Compatibility under Stability. If any of these effects persist or worsen, tell your doctor or promptly. The liquid form of amoxicillin may also be taken by itself or mixed with formulas, milk, fruit juice, water, ginger ale, or other cold drinks. If mixed with other liquids, take immediately after mixing. Be sure to drink all the liquid to get the full dose of medicine. Most children go home about four hours after surgery and require a week to 10 days to recover from it. Almost all children will have throat pain, ranging from mild to severe, after surgery. Some strengths of the amoxicillin chewable tablets contain aspartame, which is changed by the body to phenylalanine, a substance that is harmful to patients with phenylketonuria. Cavanzo FJ, Garcia CF, Botero RC "Chronic cholestasis, paucity of bile ducts, red cell aplasia, and the Stevens-Johnson syndrome. This effect may also occur with UNASYN. No dosage adjustments except those related to renal impairment. See Renal Impairment under Dosage and Administration. Stability studies on Ampicillin sodium at several concentrations in various intravenous solutions indicate the drug will lose less than 10% activity at the temperatures noted for the time periods stated. Rash: Appearance of a rash should be carefully evaluated to differentiate a nonallergic ampicillin rash from a hypersensitivity reaction; rash occurs in 5% to 10% of children and is a generalized dull red, maculopapular rash, generally appearing 3 to 14 days after the start of therapy. It normally begins on the trunk and spreads over most of the body. It may be most intense at pressure areas, elbows, and knees. Oral formulation should not be given as an initial dose.
Call your doctor if you think that your baby's skin on the tummy, arms, or legs is getting yellow or that yellowing on the face is getting worse. Doses for children should not exceed doses recommended for adults. Enoxaparin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Most tonsillectomies involve using a conventional scalpel to remove the tonsils; however there are many alternatives to this traditional method. Increasingly doctors are using techniques such as lasers, radio waves, ultrasonic energy, or electrocautery to cut, burn, or evaporate away enlarged tonsils. The most commonly encountered acute adverse experiences which demand immediate counter-measures are related to the central nervous system and the cardiovascular system. These adverse experiences are generally dose related and due to high plasma levels which may result from overdosage, rapid absorption from the injection site, diminished tolerance, or from unintentional intravascular injection of the local anesthetic solution. In addition to systemic dose-related toxicity, unintentional subarachnoid injection of drug during the intended performance of caudal or lumbar epidural block or nerve blocks near the vertebral column especially in the head and neck region may result in underventilation or apnea "Total or High Spinal". Also, hypotension due to loss of sympathetic tone and respiratory paralysis or underventilation due to cephalad extension of the motor level of anesthesia may occur. This may lead to secondary cardiac arrest if untreated. Patients over 65 years, particularly those with hypertension, may be at increased risk for experiencing the hypotensive effects of Marcaine. Factors influencing plasma protein binding, such as acidosis, systemic diseases which alter protein production, or competition of other drugs for protein binding sites, may diminish individual tolerance. Pregnancy Category C: There are no adequate and well-controlled studies in pregnant women. Marcaine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Bupivacaine hydrochloride produced developmental toxicity when administered subcutaneously to pregnant rats and rabbits at clinically relevant doses. This does not exclude the use of Marcaine at term for obstetrical anesthesia or analgesia. Ampicillin Capsules, USP 250 mg: Each capsule contains ampicillin trihydrate equivalent to 250 mg ampicillin. The number 2 size capsule has a gray opaque body with a light blue opaque cap, printed WC402. Eftects: Category B: studies in animals have revealed no evidence of impaired fertility or harm to the due to penicillin. There are, however, no adequate and well-controlled studies in women. Because animal reproduction studies are not always predictive of human response, penicillin should be used during pregnancy only if clearly needed. Tell your doctor you use enoxaparin before you have any type of spinal or epidural procedure. Patients who have these procedures while they use enoxaparin are at risk for developing bleeding around your spine. This could result in long-term or permanent paralysis. Safety and efficacy for the treatment of skin and skin structure infections have not been established in patients younger than 1 year. Safety and efficacy for the treatment of intraabdominal infections have not been established in patients younger than 18 years. Safety and efficacy of IM administration have not been established in patients younger than 18 years. UNASYN is generally well tolerated. The following adverse reactions have been reported in clinical trials. This has been demonstrated in view, however, the clinical significance of this interaction is not well documented. astelin
Other drugs may interact with ampicillin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. After the diagnosis of pseudomembranous colitis has been established, therapeutic measures should be initiated. Mild cases of pseudomembranous colitis usually respond to discontinuation of the drug alone. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial drug clinically effective against C. difficile colitis. See for additional information. To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you have a ”strep” infection, you should keep taking this medicine for at least 10 days. This is especially important in ”strep” infections. Serious heart problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return. Repeat these steps for your other eye if so directed. Apply the medication usually 1 to 3 times daily or as directed by your doctor. At the back of your throat, two masses of tissue called act as filters, trapping germs that could otherwise enter your airways and cause infection. They also produce antibodies to fight infection. But sometimes the themselves become infected. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. Single-dose ampuls and single-dose vials of Marcaine without epinephrine do not contain sodium metabisulfite. If you take too much of your NSAID, call your healthcare provider or get medical help right away. Infusion: Rapid infusion may cause seizures. Adjust rate of infusion so that the total dose is administered before admixture stability expires.
When selecting or modifying anti-infective therapy, use results of culture and in vitro susceptibility testing. 1 2 In the absence of such data, consider local epidemiology and susceptibility patterns when selecting anti-infectives for empiric therapy. This medicine may be harmful if swallowed. Dermatologic side effects have included rash, maculopapular rash, morbilliform rash, exfoliative dermatitis, erythema multiforme, purpura, urticaria, pruritus, and acute generalized exanthematous pustulosis. Rashes have been reported in patients with infectious mononucleosis and Epstein-Barr virus. Ampicillin has also been associated with a case of reactivation of latent Epstein-Barr virus infection and rash. Likewise, solutions of Marcaine containing a vasoconstrictor, such as epinephrine, should be used with extreme caution in patients receiving monoamineoxidase inhibitors MAOI or antidepressants of the triptyline or imipramine types, because severe prolonged hypertension may result. If necessary, use drugs to control the convulsions. A 50 mg to 100 mg bolus IV injection of succinylcholine will paralyze the patient without depressing the central nervous or cardiovascular systems and facilitate ventilation. Serious and occasionally fatal hypersensitivity anaphylactoid reactions have been reported in patients on penicillin therapy. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral penicillins. What other drugs will affect ampicillin Principen? Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use NSAIDs for a condition for which it was not prescribed. Do not give NSAIDs to other people, even if they have the same symptoms that you have. It may harm them. Mean half-life values were approximately 1 hour. buy periactin online singapore
Lidocaine Hydrochloride Injection USP, or 2% Lidocaine Hydrochloride Injection USP; the manufacturer product information should be consulted further guidance. Get medical help right away if your baby is jaundiced and is hard to wake, acts very fussy, or is not feeding well. Susceptible"S indicates that the pathogen is likely to be inhibited by usually achievable concentrations of the antimicrobial compound in the blood. A report of "Intermediate" I indicates that the result should be considered equivocal, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of the drug can be used. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of "Resistant" R indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. Hanline MH "Acute pancreatitis caused by ampicillin. Like other β-lactam antibiotics, antibacterial activity results from inhibition of bacterial cell wall synthesis. You may be able to help prevent kernicterus by being aware of the symptoms of jaundice and making sure your baby gets testing and treatment when needed. Patients undergoing hemodialysis should receive a supplemental dose after each dialysis period. Ampicillin Capsules, USP 500 mg: Each capsule contains ampicillin trihydrate equivalent to 500 mg ampicillin. The number 0 size capsule has a gray opaque body with a light blue opaque cap, printed WC404. Do not use after the expiration date on the label. The medicine may not work properly after that date. If you have any questions about this, check with your pharmacist. UNASYN, as with other beta-lactam antibacterials. Ampicillin has been shown to be active against most isolates of the following bacteria, both in vitro and in clinical infections, as described in the section. Respiratory tract infections: Treatment of respiratory tract infections caused by nonpenicillinase-producing H. influenzae and staphylococci, and streptococci, including Streptococcus pneumoniae.
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Hodgman T, Dasta JF, Armstrong DK, Visconti JA, Reilley TE "Ampicillin-associated seizures. Maximum dosage limit must be individualized in each case after evaluating the size and physical status of the patient, as well as the usual rate of systemic absorption from a particular injection site. CONCENTRATION OF Marcaine IS NOT RECOMMENDED FOR OBSTETRICAL ANESTHESIA. In the practice of caudal or lumbar epidural block, occasional unintentional penetration of the subarachnoid space by the catheter or needle may occur. Subsequent adverse effects may depend partially on the amount of drug administered intrathecally and the physiological and physical effects of a dural puncture. A high spinal is characterized by paralysis of the legs, loss of consciousness, respiratory paralysis, and bradycardia. epoetin-alfa
IV dose excreted unchanged in urine. Units, injected into a vein or muscle every four to six hours. This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases. Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.
After reconstitution, discard after 7 days if stored at room temperature or after 14 days if refrigerated. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Units per pound of body weight, injected into a muscle once a day. R-enantiomer. The increase in volume of distribution of Ketorolac tromethamine implies an increase in unbound fraction. order now varenicline shopping usa
F for 15 minutes. The non-beta-lactamase producing organisms which are normally susceptible to ampicillin, such asS treptococci, will have similar zone sizes as for ampicillin disks. Hepatic: Increased AST ALT alkaline phosphatase, and LDH. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor if severe diarrhea occurs. Severe diarrhea may be a sign of a serious side effect. Do not take any diarrhea medicine without first checking with your doctor. Diarrhea medicines may make your diarrhea worse or make it last longer.